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Updated: Aug 8, 2026
08:19
Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
Antiphospholipid antibodies and pregnancy: maternal implications
1Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City.
Seminars in Perinatology
|April 1, 1990
Summary
Antiphospholipid antibodies (aPLA) increase risks for pregnant women, including stroke and early preeclampsia. Early recognition and management of aPLA in pregnancy are crucial to prevent fetal loss and thromboembolic events.
Area of Science:
- Obstetrics and Gynecology
- Immunology
- Neurology
Background:
- Antiphospholipid antibodies (aPLA) are linked to serious medical conditions.
- Certain conditions associated with aPLA are of particular concern during pregnancy.
Purpose of the Study:
- To highlight the obstetric implications of antiphospholipid antibodies.
- To emphasize the importance of recognizing aPLA in pregnant patients for management.
Main Methods:
- Review of medical conditions associated with antiphospholipid antibodies.
- Focus on pregnancy-related complications and neurological events.
Main Results:
- Untreated pregnant women with aPLA face increased risk of thrombotic events, including stroke.
- Atypical early-onset preeclampsia is common in women with aPLA and prior pregnancy loss.
- aPLA are associated with postpartum pleuropulmonary disease, thrombosis, TIAs, and chorea gravidarum.
Conclusions:
- Recognition of aPLA in pregnant women is vital for appropriate management.
- Management aims to prevent fetal loss and thromboembolic complications.
- aPLA represent a significant risk factor in obstetric care.
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