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Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: May 29, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
08:01

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Published on: February 27, 2026

Abnormal activated partial thromboplastin time and malignancy.

M Delicata1, H Hambley

  • 1LAT-ST3 General Medicine, Department of Medicine, Dr. Gray's Hospital, Elgin, UK. mark.delicata@gmail.com

Scottish Medical Journal
|August 30, 2011
PubMed
Summary
This summary is machine-generated.

Cancer patients may experience abnormal blood clotting. A case study highlights lupus anticoagulant causing prolonged activated partial thromboplastin time in a mesothelioma patient, emphasizing the need for pre-procedure coagulation checks in malignancy.

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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Last Updated: May 29, 2026

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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Published on: September 9, 2012

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Malignancy is frequently associated with complex hemostasis dysfunctions.
  • The precise mechanisms underlying cancer-related coagulation abnormalities remain incompletely elucidated.

Observation:

  • A patient diagnosed with malignant mesothelioma presented with laboratory findings of an elevated activated partial thromboplastin time.
  • Further investigation revealed the presence of lupus anticoagulant as the causative factor for the prolonged activated partial thromboplastin time.

Findings:

  • Lupus anticoagulant can be a significant contributor to hemostasis abnormalities in cancer patients.
  • This specific case demonstrates a link between malignant mesothelioma and the development of lupus anticoagulant.

Implications:

  • Routine coagulation screening is recommended for patients with malignancy before undergoing invasive procedures.
  • Early detection of clotting abnormalities can aid in preventing complications and optimizing patient management in oncology settings.