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Microfluidic proportional flow controller.

Harrison Prentice-Mott¹, Mehmet Toner, Daniel Irimia

¹Harvard School of Engineering and Applied Sciences, Cambridge, MA 02129, USA.

Journal of Micromechanics and Microengineering : Structures, Devices, and Systems

|August 30, 2011

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Researchers developed a new on-chip flow controller for microfluidic chips, achieving both fast response times and precise fluid control. This technology enhances microscale experiments and biochemical assays.

Area of Science:

Engineering
Biotechnology
Fluid Dynamics

Background:

Precise flow control is crucial for microfluidic applications like biochemical assays.
Existing technologies offer either high-speed or high-precision flow control, but rarely both simultaneously.

Purpose of the Study:

To introduce a novel on-chip, pneumatically activated flow controller for microfluidic systems.
To demonstrate simultaneous fast and precise fluid flow regulation.

Main Methods:

Development of an on-chip, pneumatically activated proportional flow controller.
Experimental validation of the controller's performance.
Numerical simulations to explore potential improvements.

Main Results:

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The developed proportional flow controllers demonstrated a response time of approximately 250 ms.
Numerical simulations indicated potential for response times as low as 50 ms with alternative actuation.

Conclusions:

The new on-chip flow controller successfully integrates fast and precise flow regulation capabilities.
This advancement holds promise for improving microfluidic experiments and assays requiring dynamic flow control.