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Related Concept Videos

Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Updated: May 29, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Shaping the Genome with Non-Coding RNAs.

Xue Q D Wang1, Jennifer L Crutchley, Josée Dostie

  • 1Department of Biochemistry, and Goodman Cancer Research Center, McGill University, 3655 Promenade Sir-William- Osler, Room 815A, Montréal, Québec, H3G1Y6, Canada.

Current Genomics
|August 30, 2011
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are newly identified regulators of gene expression. These molecules influence genome organization and three-dimensional chromatin structure, impacting transcriptional control.

Keywords:
Chromatinepigeneticsgene regulationnon-coding RNApolycomb repression complexribonucleoprotein complextranscription.

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

Related Experiment Videos

Last Updated: May 29, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

Area of Science:

  • Genomics
  • Molecular Biology
  • Epigenetics

Background:

  • The human genome is highly organized within the cell nucleus to regulate gene expression.
  • Three-dimensional chromatin organization is a key mechanism controlling transcription.
  • Techniques like chromosome conformation capture (3C) study genome structure.

Purpose of the Study:

  • To review known long non-coding RNA (lncRNA) roles in gene transcription regulation.
  • To explore potential mechanisms of lncRNA-mediated 3D genome control.
  • To summarize recent findings on lncRNAs in genome shaping.

Main Methods:

  • Literature review of studies on lncRNAs and genome organization.
  • Analysis of 3C-related technologies for chromatin contact measurement.
  • Discussion of emerging research on lncRNA functions.

Main Results:

  • lncRNAs are abundant, tissue-specific molecules involved in gene regulation.
  • lncRNAs may exert transcriptional control through 3D genome organization.
  • The precise mechanisms of lncRNA action on transcription are still under investigation.

Conclusions:

  • lncRNAs represent a novel class of regulators impacting genome structure and function.
  • Further research is needed to fully understand how lncRNAs control gene expression via 3D chromatin.
  • lncRNAs play a significant role in shaping the genome's functional architecture.