Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Magnetic resonance fingerprinting of the bladder is feasible in men with lower urinary tract symptoms.

Abdominal radiology (New York)·2026

Same author

A Step Closer to the Promise of Quantitative MRI for Prostate Cancer.

Radiology·2026

Same author

Removal of Mini-Sling Anchor With Magnetic Resonance Imaging-Guided Site Marking With Methylene Blue.

O&G open·2026

Same author

Learning neuroimaging models from health system-scale data.

Nature biomedical engineering·2026

Same author

MRI and Implant Safety at Low-Field and Ultralow-Field Strengths.

Journal of magnetic resonance imaging : JMRI·2025

Same author

Health system learning achieves generalist neuroimaging models.

Research square·2025

Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 29, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

High field diffusion tensor imaging in small animals and excised tissue.

Bernadette Erokwu¹, Chris Flask, Vikas Gulani

¹Department of Radiology, Case Western Reserve University, Cleveland, OH, USA. boe@case.edu

Methods in Molecular Biology (Clifton, N.J.)

|August 30, 2011

Summary

This summary is machine-generated.

This guide explains Diffusion Tensor Imaging (DTI) principles and methods for high-field MRI scanners. It details practical steps for small animal imaging, aiding researchers new to DTI.

More Related Videos

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Related Experiment Videos

Last Updated: May 29, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Area of Science:

Biomedical Imaging
Neuroscience
Physics

Background:

Molecular diffusion is crucial in biological processes.
Magnetic Resonance (MR) imaging detects diffusion, aiding study.
Diffusion MR imaging is vital for brain ischemia, tumors, and demyelination.

Purpose of the Study:

To present a stepwise methodology for Diffusion Tensor Imaging (DTI) using small-bore, high-field strength scanners (>3 T).
To provide a basic explanation of DTI principles and a practical experimental approach for readers with no prior DTI knowledge.

Main Methods:

Utilizing small-bore, high-field strength MRI scanners (>3 T).
Stepwise methodology for DTI acquisition and analysis.
Focus on in vivo and ex vivo small animal imaging.

Main Results:

High-resolution and exquisite contrast achievable in small animal DTI.
Demonstration of practical challenges and solutions specific to small-bore, high-field scanners.

Conclusions:

Diffusion Tensor Imaging (DTI) is a powerful technique for small animal research.
This methodology facilitates high-quality DTI studies on specialized MRI scanners.
Accessible guide for researchers new to DTI principles and applications.