Related Experiment Video
Updated: May 29, 2026

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology
Published on: May 23, 2025
Helicobacter pylori and oral cancer: possible association in a preliminary case control study
Anand Dayama1, Vineeta Srivastava, Mridula Shukla
1Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Abstract:
Oral cancer is the most common cancer diagnosed in Indian men and is the leading cause of cancer deaths. Helicobacter pylori have been reported to be present in 0-40% of the cases with head neck cancer. A higher percentage has been identified in laryngeal and pharangeal cancer. We here carried out a hospital-based, case- control study of 20 patients with newly diagnosed oral cancer and 20 healthy controls without any cancer to evaluate associations between H pylori infection and oral cancer using culture and 16sRNA PCR technique for bacterial identification. H pylori was isolated from the culture of three cases and one control, while three cases and two control showed PCR positivity for H Pylori 16sRNA. The odds ratio by culture was 3.0, 95% CI 0.34- 26.4 and 1.5, 95% CI 0.28-8.03 by PCR. None of the observed odds ratio was statistically significant. However, the results of this pilot study suggest a possible association of H. pylori with an increased risk of oral cancer. Additional studies in larger populations are necessary to confirm and to quantify this possible association more accurately.
Related Concept Videos
Gastritis II: Pathophysiology
Peptic Ulcer
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease I: Introduction
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Peptic Ulcer Disease II: Pathophysiology
