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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Allergic Reactions02:06

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Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

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Published on: November 16, 2018

Allergy and the bone: unexpected relationships.

Davide Gatti1, Gianenrico Senna, Ombretta Viapiana

  • 1Rheumatologic Department, University of Verona, Verona, Italy.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|August 31, 2011
PubMed
Summary

Emerging research suggests a link between allergy treatments like antihistamines and leukotriene modifiers and bone metabolism. These findings highlight potential impacts on bone resorption, formation, and fracture repair.

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Area of Science:

  • Immunology and bone biology.
  • Pharmacological effects on skeletal health.

Background:

  • Allergic diseases are increasingly prevalent.
  • Bone metabolism is crucial for skeletal integrity.
  • The interplay between allergy and bone health is an emerging area of research.

Purpose of the Study:

  • To investigate the relationship between allergy treatments and bone metabolism.
  • To explore the effects of antihistamines and leukotriene modifiers on bone resorption and formation.

Main Methods:

  • Comprehensive literature search of MEDLINE and Scopus databases.
  • Keywords included bone metabolism, bone resorption, bone formation, antihistamines, and leukotriene modifiers.
  • Studies were independently evaluated for relevance.

Main Results:

  • Leukotriene modifiers may influence fracture repair.
  • Antihistamines are hypothesized to play a role in preventing osteoporosis.
  • Vitamin D's immune-modulating effects are linked to allergic diseases and pulmonary function.

Conclusions:

  • A significant connection exists between allergy, its treatments, and bone metabolism.
  • Further research is warranted to elucidate these complex interactions.