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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

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[Liver transplant at the UMAE 25 IMSS Monterrey].

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion·2012
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Related Experiment Video

Updated: May 29, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

[Current advances in hepatitis C treatment].

Laura E Cisneros-Garza1

  • 1Unidad Médica de Atención Especializada # 25, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México. laura_cisneros@yahoo.com

Salud Publica De Mexico
|August 31, 2011
PubMed
Summary

Hepatitis C virus infection is a significant health issue in Mexico. Current treatments show limited efficacy, necessitating a review of existing and future strategies for better patient outcomes.

Area of Science:

  • Hepatology and Viral Gastroenterology
  • Infectious Diseases and Public Health

Context:

  • Hepatitis C virus (HCV) infection presents a substantial public health challenge in Mexico.
  • High-risk populations require timely diagnosis to prevent chronic disease, cirrhosis, and hepatocellular carcinoma.
  • The current standard of care (SOC) for HCV, pegylated interferon and ribavirin, demonstrates suboptimal response rates (approx. 57%) for genotype 1, the most prevalent in Mexico.

Purpose:

  • To review current therapeutic strategies for optimizing Hepatitis C virus treatment.
  • To explore future treatment modalities, including directly acting antiviral drugs (DAAs).
  • To discuss the potential for interferon-free therapy to improve sustained virological response rates.

Summary:

  • The standard of care for Hepatitis C virus (HCV) infection in Mexico has limited efficacy, with 30-60% of patients not achieving a sustained virological response.

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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

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Last Updated: May 29, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
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Published on: May 10, 2022

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Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

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Published on: September 30, 2021

  • This review examines current treatment options and future strategies, including the integration of directly acting antiviral drugs (DAAs).
  • The goal is to enhance treatment optimization and move towards interferon-free regimens for improved cure rates.

    • Impact:

    • Optimizing Hepatitis C virus treatment can reduce the incidence of chronic liver disease, cirrhosis, and hepatocellular carcinoma in Mexico.
    • The integration of novel directly acting antiviral drugs (DAAs) promises to significantly improve treatment efficacy.
    • Future interferon-free therapies aim to increase sustained virological response rates, potentially eradicating Hepatitis C virus infection.