Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

Peripheral Artery Disease V: Postoperative Nursing Management

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

Adhesion

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lipid ratios representing SCD1, FADS1, and FADS2 activities as candidate biomarkers of early growth and adiposity.

EBioMedicine·2021

Same author

Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR-/-.Leiden mice.

International journal of obesity (2005)·2016

Same author

Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity.

International journal of obesity (2005)·2015

Same author

Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV-induced usual vulvar intraepithelial neoplasia and implications for immunotherapy.

International journal of cancer·2014

Same author

Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice.

Arthritis and rheumatism·2011

Same author

Human visceral adipose tissue and the plasminogen activator inhibitor type 1.

International journal of obesity (2005)·2007

Search research articles

Related Experiment Video

Updated: May 29, 2026

Creation of Abdominal Adhesions in Mice

Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

Pathogenesis of postoperative adhesion formation.

B W J Hellebrekers¹, T Kooistra

¹Department of Obstetrics and Gynaecology, Haga Teaching Hospital, The Hague, The Netherlands. b.hellebrekers@hagaziekenhuis.nl

The British Journal of Surgery

|August 31, 2011

Summary

Adhesion formation after peritoneal trauma is driven by inflammation, which disrupts the balance between fibrin formation and dissolution. Controlling inflammation and fibrinolysis offers potential antiadhesion treatments.

More Related Videos

Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection

Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection

Published on: October 3, 2025

Related Experiment Videos

Last Updated: May 29, 2026

Creation of Abdominal Adhesions in Mice

Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection

Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection

Published on: October 3, 2025

Area of Science:

Peritoneal biology
Wound healing
Surgical pathology

Background:

Classical concept links adhesion formation to reduced peritoneal fibrinolytic activity post-trauma.
Reviews 50 years of research on adhesion pathogenesis.

Purpose of the Study:

To synthesize current understanding of adhesion formation.
To identify key factors in peritoneal adhesion development.

Main Methods:

Non-systematic literature search (1960-2010) in PubMed.
Focused on pathogenesis, fibrinolysis, coagulation, and inflammation.

Main Results:

Peritoneal damage triggers inflammation, promoting coagulation and inhibiting fibrinolysis, increasing fibrin formation.
Inflammation duration and extent critically influence fibrin imbalance and adhesion persistence.
A unifying concept highlights inflammation's central role.

Conclusions:

Targeting inflammation, coagulation, and fibrinolysis are promising antiadhesion strategies.
Further research into these pathways could yield novel treatments.