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Related Concept Videos

Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
The Synapse02:47

The Synapse

Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
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Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
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Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
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The presynaptic neuron fires an action potential that...
Neuronal Communication01:28

Neuronal Communication

Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
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Excitatory and Inhibitory Effects of Neurotransmitters

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Related Experiment Video

Updated: May 29, 2026

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
08:38

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

Published on: May 25, 2011

[The neurotransmision from the other side].

Pedro Sánchez García

    Anales De La Real Academia Nacional De Medicina
    |September 1, 2011
    PubMed
    Summary

    Scientists discovered neurohumoral transmission, a fundamental 20th-century advancement. Persecution during WWII impacted key researchers like Loewi and Dale, who later won a Nobel Prize for their work on chemical neurotransmission.

    Area of Science:

    • Neuroscience
    • History of Science

    Background:

    • The 20th century witnessed pivotal scientific breakthroughs, including understanding neuronal communication.
    • This paper details the historical discovery of neurohumoral transmission.

    Observation:

    • Key scientists like Sir Henry Dale, Otto Loewi, and Walter Cannon faced significant social and political challenges.
    • Loewi and Felberg, targeted as Jews, were arrested by Nazi troops; Krayer faced repercussions for refusing Nazi affiliation.

    Findings:

    • These scientists, forced to migrate, received crucial support from Sir Henry Dale in Great Britain.
    • Their collective work on chemical neurotransmission culminated in the 1936 Nobel Prize for Loewi and Dale.

    Implications:

    • The discovery of neurohumoral transmission revolutionized neuroscience.

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  • The study highlights the profound impact of historical events on scientific progress and individual lives.