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Foscarnet-induced penile ulceration.

T Torres¹, I Fernandes, M Sanches

¹Department of Dermatology, Centro Hospitalar do Porto - Hospital de Santo António, Edifício das Consultas Externas do Hospital Geral Santo António, Ex CICAP, Rua D Manuel II, 4100 Porto, Portugal. tiagotorres2002@hotmail.com

Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica

|September 1, 2011

Summary

Intravenous foscarnet, used for herpes virus infections, can cause penile ulcers. This case study details severe penile ulceration following foscarnet treatment, highlighting a rare adverse effect.

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Area of Science:

Virology
Dermatology
Pharmacology

Background:

Foscarnet is a critical antiviral medication for treating infections caused by herpes viruses, including drug-resistant cytomegalovirus (CMV) and herpes simplex viruses (HSV-1, HSV-2).
Previous literature includes isolated reports of intravenous foscarnet causing genital ulcerations, specifically penile and vulvar lesions.

Observation:

This report details a clinical case of a patient who developed severe penile ulcers.
The onset of these ulcers occurred subsequent to the initiation of intravenous foscarnet therapy.

Findings:

The case demonstrates a direct correlation between intravenous foscarnet administration and the development of severe penile ulceration.
This finding underscores a potentially serious, albeit rare, adverse dermatological reaction to foscarnet therapy.

Implications:

Clinicians should be vigilant for genital ulceration as a potential side effect in patients receiving intravenous foscarnet.
Further investigation into the mechanism and incidence of foscarnet-induced genital ulcers may be warranted.
Awareness of this adverse effect is crucial for patient management and treatment decisions involving foscarnet.