Related Experiment Video
Updated: May 29, 2026
07:02
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
Intercellular adhesion molecule-1 (ICAM-1) is upregulated in aggressive papillary thyroid carcinoma
D Buitrago1, X M Keutgen, M Crowley
1Division of Endocrine and Minimally Invasive Surgery, Department of Surgery, New York Presbyterian Hospital-Weill Cornell Medical College, New York, USA.
Annals of Surgical Oncology
|September 1, 2011
Summary
Intercellular adhesion molecule-1 (ICAM-1) is upregulated in papillary thyroid cancer (PTC). Higher ICAM-1 levels correlate with aggressive features like BRAF V600E mutation and lymph node metastasis, indicating its role in PTC progression.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Intercellular adhesion molecule-1 (ICAM-1) is recognized for its role in carcinogenesis.
- This study investigates ICAM-1 expression in papillary thyroid cancer (PTC).
- The hypothesis posits a correlation between ICAM-1 and indicators of PTC aggressiveness.
Purpose of the Study:
- To determine ICAM-1 expression levels in PTC compared to benign thyroid conditions.
- To investigate the association between ICAM-1 expression and established markers of tumor aggressiveness in PTC.
Main Methods:
- Quantitative reverse-transcription polymerase chain reaction (RT-PCR) for ICAM-1 gene expression analysis.
- Immunohistochemistry (IHC) for semiquantitative assessment of ICAM-1 protein levels.
- Correlation analysis of ICAM-1 levels with BRAF V600E mutation, tumor size, extrathyroidal extension (ETE), angiolymphatic invasion, and lymph node metastasis.
Main Results:
- ICAM-1 gene expression was significantly higher in PTC and lymph node metastases compared to benign tissues.
- Elevated ICAM-1 levels were associated with BRAF V600E mutation, ETE, and lymph node metastasis in PTC.
- A positive correlation was observed between ICAM-1 gene expression and protein levels, with poorly differentiated carcinoma showing higher ICAM-1 intensity.
Conclusions:
- ICAM-1 expression is demonstrably upregulated in papillary thyroid carcinoma.
- ICAM-1 upregulation is linked to aggressive tumor characteristics, including BRAF V600E mutation, ETE, and lymph node metastasis.
- These findings suggest ICAM-1 plays a significant role in the progression of thyroid cancer.
Related Concept Videos
01:31Immunoglobulin-like Cell Adhesion Molecules
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
01:17Intracellular Signaling Affects Focal Adhesions
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
01:19Cadherins in Tissue Organization
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
01:15Activation of Integrins
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
01:20Cell Adhesion Molecules - Types and Functions
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...
CAM Families
The Integrin family of proteins is primarily involved in a...
01:35Cancer Cell Migration through Invadopodia
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...