Related Experiment Video
Updated: May 29, 2026

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
Published on: March 28, 2017
Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment
Mostafa E Rateb1, Wael E Houssen, William T A Harrison
1Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK.
Abstract:
The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.
Related Concept Videos
Bacterial Phylum Actinobacteria
Deep Sea Microbial Ecology
Diversity of Archaea IV
Diversity of Archaea I
Bioreactor Controls-III
Diversity of Archaea III

