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[Ru(bpy)2(5-cyanouracil)2]2+ as a potential light-activated dual-action therapeutic agent
Robert N Garner1, Judith C Gallucci, Kim R Dunbar
1Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Abstract:
The cation cis-[Ru(bpy)(2)(5CNU)(2)](2+) (bpy = 2,2'-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active 5CNU and generating [Ru(bpy)(2)(H(2)O)(2)](2+). The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therapeutic agents from a single molecule.
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