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Elevated E-selectin and diastolic blood pressure in diabetic children
Albane B R Maggio1, Nathalie J Farpour-Lambert, Fabrizio Montecucco
1Paediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva, Rue Willy-Donzé, Geneva, Switzerland. albane.maggio@hcuge.ch
European Journal of Clinical Investigation
|September 2, 2011
Summary
In children with type 1 diabetes, elevated diastolic blood pressure (BP) is linked to E-selectin, an early marker of atherosclerosis. This association exists even with short disease duration, highlighting potential cardiovascular risks.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Research
- Diabetes Complications
Background:
- Cardiovascular risk markers are associated with micro-angiopathy in children with type 1 diabetes (T1DM).
- Limited data exists on the relationship between these markers, blood pressure (BP), and endothelial function in pediatric T1DM.
- Understanding these links is crucial for early detection and management of cardiovascular risks.
Purpose of the Study:
- To investigate the relationship between cardiovascular risk markers, BP, and endothelial function in children with T1DM.
- To compare these parameters between children with T1DM and healthy controls.
Main Methods:
- A case-control study involving 29 children with T1DM and 39 healthy controls.
- Assessment of 24-hour ambulatory BP, vascular function, and serum levels of lipids, VCAM-1, E-selectin, and P-selectin.
- Statistical analysis to determine associations and differences between groups.
Main Results:
- Children with T1DM exhibited higher body mass index (BMI) and increased 24-hour diastolic BP z-scores compared to controls, even after adjusting for BMI.
- Elevated VCAM-1 concentrations were observed in children with T1DM.
- Diastolic BP z-scores in the T1DM group were associated with disease duration, E-selectin, and triglyceride levels.
Conclusions:
- E-selectin, an early biomarker for atherosclerosis, shows a positive association with diastolic BP in children with T1DM.
- This finding suggests a potential link between early vascular changes and elevated BP in pediatric T1DM, even with short disease duration.
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