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Related Experiment Video

Updated: May 29, 2026

Live Cell Imaging of Alphaherpes Virus Anterograde Transport and Spread

Live Cell Imaging of Alphaherpes Virus Anterograde Transport and Spread

Published on: August 16, 2013

Single-virus tracking in live cells.

Michael J Rust, Melike Lakadamyali, Boerries Brandenburg

Cold Spring Harbor Protocols

|September 2, 2011

Summary

This summary is machine-generated.

Live-cell imaging and single-particle tracking visualize individual virus infections. This approach analyzes viral transport and interactions with cellular machinery during infection.

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Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy

Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy

Published on: November 4, 2018

Related Experiment Videos

Last Updated: May 29, 2026

Live Cell Imaging of Alphaherpes Virus Anterograde Transport and Spread

Live Cell Imaging of Alphaherpes Virus Anterograde Transport and Spread

Published on: August 16, 2013

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

Published on: December 16, 2017

Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy

Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy

Published on: November 4, 2018

Area of Science:

Virology
Cell Biology
Biophysics

Background:

Viral infections involve complex interactions between virus particles and host cells.
Understanding these interactions at a single-particle level is crucial for deciphering infection mechanisms.

Purpose of the Study:

To describe methods for visualizing and analyzing individual virus particles during live-cell infection.
To outline techniques for tracking viral trajectories and quantifying virus-cell interactions.

Main Methods:

Labeling viruses and cellular structures with fluorescent probes for live-cell imaging.
Utilizing time-lapse microscopy and single-particle tracking algorithms.
Employing inhibitors and reagents to investigate cellular machinery roles.

Main Results:

Successful visualization of individual virus particles during the infection process.
Quantitative analysis of virus trajectories and interactions with cellular components.
Insights into the dynamics of viral transport within host cells.

Conclusions:

Real-time, live-cell imaging combined with single-particle tracking provides powerful tools to study viral infections.
These techniques enable detailed analysis of virus-cell interactions and the role of cellular factors.
This approach facilitates a deeper understanding of viral pathogenesis and infection dynamics.