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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...

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In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue
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Treating obstructive sleep apnea with hypoglossal nerve stimulation.

Arie Oliven1

  • 1Department of Internal Medicine B, Bnai-Zion Medical Center, Rappaport Faculty of Medicine, Technion, Israel. oliven@tx.technion.ac.il

Current Opinion in Pulmonary Medicine
|September 2, 2011
PubMed
Summary

Hypoglossus nerve stimulation shows promise for treating obstructive sleep apnea (OSA). This implantable device significantly reduces the apnea-hypopnea index (AHI) in many patients, offering a potential new therapy for OSA.

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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

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Area of Science:

  • Sleep Medicine
  • Neurosurgery
  • Biomedical Engineering

Background:

  • Obstructive sleep apnea (OSA) involves pharyngeal collapse during sleep.
  • Current OSA therapies can be poorly tolerated or ineffective.
  • Hypoglossus nerve stimulation is an emerging treatment modality for OSA.

Purpose of the Study:

  • To review the current evidence for hypoglossus nerve stimulation as a treatment for OSA.
  • To assess the efficacy and safety of hypoglossus nerve stimulation systems.
  • To discuss the future availability and patient selection for this therapy.

Main Methods:

  • Review of published physiological and clinical studies on hypoglossus nerve stimulation.
  • Analysis of data from phase-I and ongoing phase-III multicenter trials.
  • Evaluation of hypoglossus nerve stimulation system designs and efficacy.

Main Results:

  • Early studies reported significant apnea-hypopnea index (AHI) reduction in OSA patients.
  • Recent evaluations of three new systems show >50% AHI reduction in selected patients.
  • Treatment often decreases OSA severity from moderate-severe to mild-minimal.

Conclusions:

  • Hypoglossus nerve stimulators are anticipated to be available within years.
  • Further research is needed to identify optimal patient candidates for this therapy.
  • Ongoing refinement of electrode design may enhance stimulation efficacy.