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High-density lipoprotein cholesterol. Recommendations for routine testing and treatment
C J Lavie1, J H O'Keefe, L Blonde
1Ochsner Clinic, New Orleans, LA 70121.
Insights
High-density lipoprotein cholesterol (HDL-C) is crucial for managing coronary artery disease (CAD) risk. Measuring HDL-C levels and treating low levels with lifestyle changes or medication is recommended for all patients.
Area of Science:
- Cardiovascular Medicine
- Lipidology
- Preventive Cardiology
Background:
- High-density lipoprotein cholesterol (HDL-C) plays a significant role in cardiovascular health.
- Epidemiologic, interventional, and angiographic studies highlight the link between HDL-C and coronary artery disease (CAD).
Purpose of the Study:
- To emphasize the clinical importance of measuring HDL-C levels in patients.
- To recommend management strategies for varying HDL-C levels in CAD risk assessment.
Main Methods:
- Review of evidence from epidemiologic studies.
- Analysis of data from lipid intervention trials.
- Evaluation of findings from coronary angiographic research.
Main Results:
- Consistent evidence demonstrates HDL-C's critical role in CAD risk.
- Strong support exists for routine HDL-C measurement in CAD screening.
- Low HDL-C levels are associated with increased CAD risk.
Conclusions:
- HDL-C measurement is essential for all patients undergoing CAD screening.
- Nonpharmacologic interventions are advised for patients with low HDL-C levels.
- Pharmacologic treatment should be considered for high-risk individuals with low HDL-C.
Abstract:
Evidence from epidemiologic, lipid intervention, and coronary angiographic studies demonstrates the importance of high-density lipoprotein cholesterol (HDL-C) in coronary artery disease (CAD) risk. Data from these studies strongly support the measurement of HDL-C in all patients screened for CAD. Patients with low levels should be treated using nonpharmacologic measures. High-risk patients deserve consideration for specific drug treatment.