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Fibrous dysplasia.

M J Kransdorf1, R P Moser, F W Gilkey

  • 1Department of Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000.

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|May 1, 1990
PubMed
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Fibrous dysplasia is a bone disorder where marrow is replaced by fibrous tissue. This study details the wide range of radiologic findings for this condition.

Area of Science:

  • Radiology
  • Pathology
  • Orthopedics

Background:

  • Fibrous dysplasia is a rare developmental anomaly of bone.
  • Characterized by the replacement of normal bone marrow with fibro-osseous tissue.
  • Can manifest as monostotic (single bone) or polyostotic (multiple bones) disease.

Purpose of the Study:

  • To present the spectrum of radiologic findings in fibrous dysplasia.
  • To correlate radiologic findings with pathological data.
  • To illustrate the utility of various imaging modalities in diagnosing fibrous dysplasia.

Main Methods:

  • Retrospective review of 501 histologically proven cases of fibrous dysplasia from the AFIP archives.
  • Analysis of radiologic findings from plain radiography, bone scintigraphy, computed tomography (CT), and magnetic resonance imaging (MRI).

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  • Correlation of imaging findings with available histopathological data.
  • Main Results:

    • The study encompasses 427 cases of monostotic and 74 cases of polyostotic fibrous dysplasia.
    • Detailed description of the characteristic radiologic appearances across different imaging techniques.
    • Pathologic correlation confirms the imaging diagnoses.

    Conclusions:

    • Fibrous dysplasia exhibits a diverse range of radiologic manifestations.
    • Multimodality imaging, including bone scintigraphy, CT, and MRI, is crucial for comprehensive evaluation.
    • Radiologic-pathologic correlation aids in accurate diagnosis and understanding of this developmental anomaly.