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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
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Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

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Related Experiment Video

Updated: May 29, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

Clopidogrel "resistance": where are we now?

Zeshan Qureshi1, Alex R Hobson

  • 1Wessex Cardiothoracic Unit, Southampton University Hospital, Southampton, UK. Zeshan.u.qureshi@gmail.com

Cardiovascular Therapeutics
|September 3, 2011
PubMed
Summary

Clopidogrel resistance in PCI patients is linked to thrombotic events. Personalized antiplatelet therapy, guided by platelet function tests, is crucial for managing poor drug response and improving outcomes.

Area of Science:

  • Cardiology
  • Pharmacology
  • Interventional Cardiology

Background:

  • Antiplatelet therapy with aspirin and clopidogrel is standard for percutaneous coronary intervention (PCI) patients.
  • Despite efficacy, thrombotic complications persist, partly due to clopidogrel resistance.
  • Current management strategies for clopidogrel resistance are not well-defined.

Purpose of the Study:

  • To review the definition, mechanisms, and assessment of clopidogrel resistance.
  • To explore management strategies for patients with poor clopidogrel response.
  • To discuss newer antiplatelet agents and stent technologies in the context of clopidogrel resistance.

Main Methods:

  • A literature review was conducted using PubMed.
  • Keywords included "clopidogrel", "resistance", "platelet function tests", "genetic tests", "prasugrel", "ticagrelor", and "stent technology".

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Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

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Last Updated: May 29, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Main Results:

  • Poor response to clopidogrel is associated with adverse outcomes.
  • Platelet function testing appears more clinically useful than genetic testing for assessing resistance.
  • Newer P2Y12 receptor antagonists and advanced stent technology may reduce future thrombotic events.

Conclusions:

  • A "one size fits all" approach to clopidogrel dosing is likely inadequate.
  • Identifying and managing individual variability in clopidogrel response requires further research.
  • While new agents and technologies are promising, clopidogrel remains important, necessitating effective resistance management.