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Updated: May 29, 2026

Quantitative 3D Imaging of Trypanosoma cruzi-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs
Published on: June 23, 2022
ROS signalling of inflammatory cytokines during Trypanosoma cruzi infection
Shivali Gupta1, Monisha Dhiman, Jian-Jun Wen
1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA.
Abstract:
Inflammation is a host defence activated by exogenous (e.g. pathogen-derived, pollutants) or endogenous (e.g. reactive oxygen species-ROS) danger signals. Mostly, endogenous molecules (or their derivatives) have well-defined intracellular function but become danger signal when released or exposed following stress or injury. In this review, we discuss the potential role of ROS in chronic evolution of inflammatory cardiovascular diseases, using our experiences working on chagasic cardiomyopathy as a focus-point.
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