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Updated: May 29, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

Allergy blood testing: A practical guide for clinicians.

Roxana I Siles¹, Fred H Hsieh

¹Respiratory Institute, A90, Cleveland Clinic, OH 44195, USA.

Cleveland Clinic Journal of Medicine

|September 3, 2011

Summary

Specific blood tests can measure immunoglobulin E (IgE) levels to diagnose allergic disorders. These tests are valuable when skin testing is not feasible, confirming immediate allergic reactions.

Area of Science:

Clinical immunology
Diagnostic medicine

Background:

Allergic disorders affect a significant portion of the population.
Accurate diagnosis is crucial for effective management of allergies.

Purpose of the Study:

To highlight the utility of specific immunoglobulin E (IgE) blood tests in diagnosing allergic disorders.
To present IgE blood tests as a diagnostic alternative to skin testing.

Main Methods:

Measurement of serum IgE levels against a panel of specific allergens.
Utilizing clinical history to supplement blood test results.

Main Results:

Blood tests accurately measure IgE levels to specific allergens including foods, inhalants, medications, latex, and venoms.

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IgE blood tests confirm diagnoses of allergic disorders.

Conclusions:

Specific IgE blood tests are a reliable tool for diagnosing allergic conditions.
These tests are particularly useful for patients where skin testing is contraindicated or not possible.