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Related Concept Videos

Gastrointestinal Motility Disorders01:20

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Related Experiment Video

Updated: Feb 7, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Gastrointestinal Involvement in Mast Cell Activation Disorders.

Fred H Hsieh1

  • 1Allergy and Immunology, Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, A90, Cleveland, OH 44195, USA.

Immunology and Allergy Clinics of North America
|July 16, 2018
PubMed
Summary

Gastrointestinal symptoms are common in mast cell diseases, stemming from mast cell infiltration or mediator effects. Anti-mediator therapy can help manage these digestive issues in mast cell activation syndromes.

Keywords:
Gastrointestinal symptomsMast cell activation disorderMast cell activation syndromeMast cell diseaseMonoclonal mast cell activation disorderMonoclonal mast cell activation syndromeSystemic mastocytosis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Hematology

Background:

  • Gastrointestinal (GI) symptoms are frequently observed in patients diagnosed with mast cell diseases.
  • GI involvement in systemic mastocytosis presents heterogeneously, with symptoms arising from direct mast cell infiltration or mediator-induced effects on GI tissues.

Purpose of the Study:

  • To summarize the role of gastrointestinal symptoms in mast cell diseases.
  • To highlight the diagnostic criteria and therapeutic approaches for mast cell activation syndromes involving the GI tract.

Main Methods:

  • Literature review of studies on mast cell diseases and GI symptoms.
  • Analysis of diagnostic criteria for mast cell activation syndromes.
  • Evaluation of therapeutic strategies, particularly anti-mediator therapy.

Main Results:

  • GI symptoms are a significant manifestation of mast cell diseases.
  • Monoclonal mast cell activation syndrome GI symptoms are often linked to acute anaphylaxis.
  • Subjective improvement with anti-mediator therapy is a key diagnostic criterion for idiopathic mast cell activation syndrome.

Conclusions:

  • Gastrointestinal symptoms are a common and important feature of mast cell diseases.
  • Anti-mediator therapy shows promise in alleviating GI symptoms associated with mast cell disorders.
  • Understanding the mechanisms and treatment of GI involvement is crucial for managing mast cell diseases.