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Updated: May 1, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.6K

Hypereosinophilic syndrome

Fred H Hsieh1

  • 1Allergy and Immunology, Respiratory Institute, Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|April 15, 2014
PubMed

Insights

Understanding the molecular and cellular mechanisms of hypereosinophilic syndrome (HES) is crucial for clinicians. Identifying these disease pathways can lead to targeted, mechanism-based treatments for HES patients.

Area of Science:

  • Hematology
  • Molecular Biology
  • Immunology

Background:

  • Hypereosinophilic syndrome (HES) is a group of disorders characterized by sustained eosinophilia.
  • Recent research has led to proposed changes in HES definitions based on identified molecular and cellular phenotypes.

Purpose of the Study:

  • To summarize molecular and cellular mechanisms of HES.
  • To provide clinicians with relevant information for patient evaluation and treatment.

Main Methods:

  • Comprehensive review of peer-reviewed literature.
  • Inclusion of studies on HES pathogenesis, definitions, classification, diagnosis, and treatment.

Main Results:

  • Proposed revisions to HES definitions are based on specific cellular and molecular disease phenotypes.
  • Specific disease mechanisms identified hold potential clinical and therapeutic significance.
  • The molecular pathogenesis of HES remains unknown in most cases despite advances.

Conclusions:

  • Identifying specific HES disease mechanisms enables clinicians to offer targeted, mechanism-based treatment options.
  • This knowledge empowers clinicians to improve patient care for hypereosinophilic syndrome.
Abstract

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