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Interactions between the brain and the immune system.

R Ader1, D Felten, N Cohen

  • 1Department of Psychiatry, University of Rochester School of Medicine and Dentistry, New York 14642.

Annual Review of Pharmacology and Toxicology
|January 1, 1990
PubMed
Summary
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Behavior significantly impacts immune function, challenging the idea of an autonomous immune system. The brain, behavior, and immune processes are interconnected, influencing health and illness.

Area of Science:

  • Psychoneuroimmunology
  • Behavioral immunology

Background:

  • The immune system's regulation is traditionally viewed as intrinsic, involving interactions within lymphoid tissues.
  • However, real-world conditions reveal that behavior and physiological events influence immune responses in humans and animals.
  • The complex interplay between the brain, behavior, and immune system is not fully understood.

Purpose of the Study:

  • To illustrate how behavior can influence immune function.
  • To demonstrate that the immune system interacts with neural and endocrine signals.
  • To question the concept of a fully autonomous immune system.

Main Methods:

  • Review of literature on stress effects and conditioning phenomena.
  • Analysis of data showing neural and endocrine signals influencing immune responses.

Related Experiment Videos

  • Examination of how immune activation affects behavioral, neural, and endocrine responses.

    • Main Results:

    • Behavior, through mechanisms like stress and conditioning, can modulate immune function.
    • The immune system receives and responds to signals from the brain and endocrine system.
    • Activated immune systems can influence neural and endocrine responses, impacting behavior.

    Conclusions:

    • A traditional, isolated view of the immune system is insufficient to explain in vivo observations.
    • The neuroendocrine environment significantly influences immune regulation, receiving signals from and responding to the immune system.
    • Behavior, particularly through learning, acts as a crucial feedforward mechanism in immune regulation.