Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyper-dimensional computing for enhanced label-free particle analysis in a flow-based optical detection system.

Scientific reports·2026
Same author

Efficient modeling and optimization approach for grating-based flow cytometers.

Optics express·2025
Same author

Accurately extracting silicon waveguide dimensions from a single high-order Mach-Zehnder Interferometer.

Optics express·2025
Same author

Shapley-guided global optimization algorithm with applications in integrated photonics inverse design.

Optics express·2025
Same author

Volatile and non-volatile nano-electromechanical switches fabricated in a CMOS-compatible silicon-on-insulator foundry process.

Microsystems & nanoengineering·2025
Same author

A Pathway for the Integration of Novel Ferroelectric Thin Films on Non-Planar Photonic Integrated Circuits.

Micromachines·2025

Related Experiment Video

Updated: May 29, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
10:59

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

Vernier-cascade label-free biosensor with integrated arrayed waveguide grating for wavelength interrogation with

Tom Claes1, Wim Bogaerts, Peter Bienstman

  • 1Department of Information Technology, Ghent University-IMEC, Ghent, Belgium. tom.claes@intec.ugent.be

Optics Letters
|September 3, 2011
PubMed
Summary

This study introduces a low-cost silicon biosensor that uses a novel spectral filter for accurate detection of biological molecules. This innovation enables affordable, portable medical diagnostics and drug development without expensive lasers.

More Related Videos

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
09:35

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Published on: May 1, 2012

Implementation of a Reference Interferometer for Nanodetection
16:11

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Related Experiment Videos

Last Updated: May 29, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
10:59

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
09:35

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Published on: May 1, 2012

Implementation of a Reference Interferometer for Nanodetection
16:11

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Area of Science:

  • Photonics
  • Biomedical Engineering
  • Materials Science

Background:

  • Silicon-on-insulator (SOI) biosensors offer cost-effective, label-free detection of biomolecules for medical diagnostics and drug development.
  • Current SOI biosensors require expensive tunable lasers for wavelength interrogation, limiting their widespread adoption.

Purpose of the Study:

  • To develop a cost-effective wavelength interrogation scheme for SOI label-free biosensors.
  • To enable accurate, real-time monitoring of biomolecular interactions using affordable components.

Main Methods:

  • Integration of a Vernier-cascade sensor with an arrayed waveguide grating (AWG) spectral filter.
  • Utilizing a broadband light source for spectral analysis instead of a tunable laser.
  • Monitoring refractive index changes in aqueous solutions.

Main Results:

  • Achieved a detection limit of 1.6 × 10⁻⁵ RIU, competitive with expensive interrogation methods.
  • Demonstrated real-time monitoring of refractive index changes.
  • Validated the sensor's applicability for low-cost, label-free biosensing.

Conclusions:

  • The developed AWG-based spectral filter enables cost-effective wavelength interrogation for SOI biosensors.
  • This approach significantly reduces the cost and complexity of biosensing systems.
  • The technology holds promise for integrated, portable, and low-cost diagnostic devices.