Related Experiment Videos
[The heart and diabetes mellitus]
I Lerman Garber1, M Ahumada Ayala, C Posadas Romero
1Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.E.
Insights
Diabetic patients experience more frequent and rapid atherosclerosis due to intrinsic factors. Early detection of cardiovascular changes in these patients is crucial for risk reduction and improved outcomes.
Area of Science:
- Cardiology
- Endocrinology
- Diabetology
Context:
- Diabetes mellitus significantly accelerates atherosclerosis, affecting both genders early and rapidly.
- This accelerated process is attributed to intrinsic diabetic factors beyond traditional risk factors.
- Coronary heart disease (CHD) prevalence and post-event mortality are markedly higher in diabetic individuals.
Purpose:
- To elucidate the unique atherosclerotic burden in diabetic patients.
- To explore the intrinsic mechanisms driving accelerated cardiovascular disease in diabetes.
- To highlight the increased morbidity and mortality associated with cardiovascular events in diabetes.
Summary:
- Diabetic patients exhibit accelerated atherosclerosis, independent of other risk factors, linked to hyperinsulinemia, lipid and coagulation disorders, hyperglycemia, and microangiopathy.
- Coronary heart disease is more prevalent in diabetics, with double the morbimortality post-myocardial infarction or revascularization.
- Cardiovascular denervation syndrome and early, subclinical cardiovascular changes in asymptomatic diabetics impact prognosis.
Impact:
- Understanding diabetes-intrinsic atherogenesis can guide targeted preventive strategies.
- Early detection of cardiovascular changes in diabetics via non-invasive tests can mitigate risks.
- This research underscores the critical need for proactive cardiovascular management in diabetic populations.
Abstract:
The atherosclerotic process in the diabetic patient, is more common, it is noticed at early ages, advances more rapidly and almost equally affects males and females. This data, can not be explained on the basis of the association with other coronary heart disease risk factors, there is an intrinsic atherogenic factor attributed to diabetes, and can be related, to the early hyperinsulinemia, coagulation and lipid disorders, hyperglycemia or diabetic microangiopathy. Coronary heart disease has an increased prevalence in diabetic patients, that is not related with diabetes duration or the type of treatment. Early and late morbimortality after acute myocardial infarction and/or revascularization surgery is twice as common in the diabetic patient. Diabetic cardiomyopathy related to small vessels disease is still a matter of controversy and many authors doubt about its relevance in clinical practice. The presence of autonomic neuropathy with the cardiovascular denervation syndrome carries a poor prognosis. Early cardiovascular changes in asymptomatic patients, are detected with non-invasive test, and can help to introduce measures to protect individuals at a greater risk.