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Published on: October 17, 2025
Transformation of myelodysplastic syndrome to acute lymphoblastic leukemia in a child
1Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005 India.
Abstract:
Childhood myelodysplastic syndrome (MDS) is an uncommon condition. Unlike adult MDS, pediatric patients have a more progressive course and rapidly transform to acute myeloid leukemia. Evolution to acute lymphoblastic leukemia is extremely rare. We report a 5 year old female child who presented with refractory anemia with excess blasts and transformed into acute lymphoblastic leukemia 4 months after initial diagnosis.

