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Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS.
1William Paterson University, Wayne NJ and Molecular Neurobiology Branch, National Institute on Drug Abuse, NIH, Baltimore, USA.
Current Neuropharmacology
|September 3, 2011
Summary
Cannabinoids from marijuana activate the body's endocannabinoid system. Research shows endocannabinoids are vital for fetal development and infant growth, with CB2 receptors in the brain now being actively studied.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Cannabinoids are compounds found in Cannabis sativa.
- The endocannabinoid system (ECS) involves cannabinoid receptors (CBRs) activated by plant-derived or body-produced compounds.
- Endocannabinoids are crucial for fetal development and infant nutrition.
Purpose of the Study:
- To review recent advancements in cannabinoid and endocannabinoid research.
- To highlight the role of endocannabinoids in pregnancy and lactation.
- To discuss the characterization and ongoing debate surrounding functional neuronal CB2 receptors (CB2-Rs) in the central nervous system (CNS).
Main Methods:
- Literature review of recent studies on cannabinoids and the ECS.
- Analysis of research on endocannabinoid roles in reproduction and development.
- Examination of studies investigating CB1 and CB2 receptor expression and function in the CNS.
Main Results:
- The ECS is a key system involving cannabinoid receptors (CBRs).
- Endocannabinoids play a critical role in pregnancy and neonatal development via breast milk.
- While CB1 receptors are abundant in the brain, the presence and function of neuronal CB2 receptors in the CNS are increasingly supported by recent research, despite ongoing debate regarding antibody specificity.
Conclusions:
- The endocannabinoid system is fundamental to mammalian physiology, particularly in reproduction and development.
- Further research into functional neuronal CB2-Rs is warranted to clarify their role in the CNS beyond neuro-immune functions.
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