Related Experiment Video

Updated: May 29, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

Stevens-Johnson syndrome associated with cytomegalovirus infection in a child with ependymoma

Maria João Cruz1, Alberto Mota, Teresa Baudrier

  • 1Department of Dermatology and Venereology, Hospital de São João, Porto, Portugal.

Journal of Dermatological Case Reports
|September 3, 2011
PubMed
Abstract

Insights

Stevens-Johnson syndrome (SJS) in children is rare and often drug-induced. This case highlights a potential link between SJS and cytomegalovirus (CMV) infection, successfully treated with IVIG and gancyclovir.

Area of Science:

  • Pediatric Infectious Diseases
  • Dermatology
  • Clinical Case Reports

Background:

  • Stevens-Johnson syndrome (SJS) is a severe, acute hypersensitivity reaction with significant epidermal and mucosal involvement.
  • While often drug-induced, infectious agents are increasingly recognized as triggers, particularly in pediatric cases.
  • Prompt recognition and management are crucial for improving patient outcomes.

Observation:

  • A 2-year-old boy with posterior fossa ependymoma developed SJS.
  • The SJS was strongly suspected to be associated with a cytomegalovirus (CMV) infection.
  • The patient received high-dose intravenous immunoglobulin (IVIG) and gancyclovir.

Findings:

  • This case represents the first reported instance of SJS associated with CMV infection.
  • Successful treatment was achieved with a combination of IVIG and gancyclovir.
  • The findings suggest CMV as a potential, albeit rare, cause of SJS in children.

Implications:

  • Highlights the importance of considering infectious etiologies, including CMV, in pediatric SJS cases.
  • Suggests IVIG and gancyclovir as a potential therapeutic strategy for SJS linked to CMV.
  • Underscores the need for further research into the role of viral infections in SJS pathogenesis.
Keywords:
Stevens-Johnson syndromechildcytomegalovirusganciclovirintravenous immunoglobulinperianal

More Related Videos

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...