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Related Experiment Video

Updated: May 29, 2026

Visualization and Quantitative Analysis of Genotoxin-Induced PARP1/PARP2 Activation in Cells Using a Fluorescent Fusion Protein-Based Reporter

Visualization and Quantitative Analysis of Genotoxin-Induced PARP1/PARP2 Activation in Cells Using a Fluorescent Fusion Protein-Based Reporter

Published on: April 17, 2026

Parry-Romberg syndrome.

Elizabeth Lazaridou¹, Christina Giannopoulou, Zoi Apalla

¹First Department of Dermatology and Venereology, Aristotle University Medical School, Thessaloniki, Greece.

Journal of Dermatological Case Reports

|September 3, 2011

Summary

Parry-Romberg syndrome (PRS), a rare condition causing facial atrophy, was diagnosed in a 14-year-old boy after nearly 9 years. Topical calcipotriol-betamethasone was used in his treatment.

Keywords:

Parry-Romberg betamethasone calcipotriol en-coupe de sabre hemifacial atrophy morphea propionate scleroderma

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Rectal Organoid Morphology Analysis (ROMA): A Diagnostic Assay in Cystic Fibrosis

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Area of Science:

Dermatology
Neurology
Rare Diseases

Background:

Parry-Romberg syndrome (PRS), or idiopathic hemifacial atrophy, is a rare neurocutaneous disorder.
Characterized by progressive, unilateral facial atrophy affecting skin, fat, and connective tissues.
Exhibits overlap with "en coupe de sabre" morphea.

Observation:

A case study of a 14-year-old boy with hemifacial atrophy is presented.
Diagnosis was based on clinical presentation and histological findings.
The diagnostic delay was approximately 9 years, aligning with literature averages.

Findings:

The patient was treated with topical calcipotriol-betamethasone ointment.
The study highlights the challenges in diagnosing PRS due to its slow progression.
Discussion includes potential complications, pathophysiology, and therapeutic strategies.

Implications:

Emphasizes the need to understand PRS pathogenesis to halt disease progression.
Addresses the significant disfigurement and potential neurological/psychiatric complications.
Underscores the difficulty in treatment selection due to limited knowledge on agent efficacy.