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Pyogenic granulomas during isotretinoin therapy
Kathleen Armstrong1, Miriam Weinstein
1Paediatric Dermatology Hospital For Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.
Journal of Dermatological Case Reports
|September 3, 2011
Summary
Periungual pyogenic granulomas are a rare side effect of isotretinoin therapy. Stopping the medication led to spontaneous resolution in four acne patients, suggesting an idiosyncratic reaction.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Isotretinoin is a common treatment for severe acne.
- Periungual pyogenic granulomas are infrequently documented as an adverse effect of isotretinoin.
Observation:
- Four patients undergoing isotretinoin therapy for acne developed periungual pyogenic granulomas.
- These lesions did not respond to standard oral or topical antibiotic treatments.
Findings:
- Periungual pyogenic granulomas resolved spontaneously after discontinuation of isotretinoin.
- The side effect appears to be idiosyncratic, not directly infectious despite skin barrier changes.
Implications:
- Clinicians should consider pyogenic granulomas in patients on isotretinoin with similar lesions.
- Discontinuation of isotretinoin is the primary effective treatment for this adverse effect.
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