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Updated: May 29, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Effect of amniotic membrane to reduce postlaminectomy epidural adhesion on a rat model
Hyu Jin Choi1, Kyoung Beom Kim, Young-Min Kwon
1Department of Neurosurgery, College of Medicine, Dong-A University, Busan, Korea.
Objective:
Epidural fibrosis and adhesion are the main reasons for post-laminectomy sustained pain and functional disability. In this study, the authors investigate the effect of irradiated freeze-dried human amniotic membrane on reducing epidural adhesion after laminectomy on a rat model.
Methods:
A total of 20 rats were divided into two groups. The group A did not receive human amniotic membrane implantation after laminectomy and group B underwent human amniotic membrane implantation after laminectomy. Gross and microscopic findings were evaluated and compared at postoperative 1, 3 and 8 weeks.
Results:
The amount of scar tissue and tenacity were reduced grossly in group of rats with human amniotic membrane implantation (group B). On a microscopic evaluation, there were less inflammatory cell infiltration and fibroblast proliferation in group B.
Conclusion:
This experimental study shows that implantation of irradiated freeze-dried human amniotic membrane reduce epidural fibrosis and adhesion after spinal laminectomy in a rat model.
