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Updated: May 29, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Reactions under the click chemistry philosophy employed in supramolecular and mechanostereochemical systems
Albert C Fahrenbach1, J Fraser Stoddart
1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
Abstract:
Supramolecular chemistry and mechanostereochemistry have been major beneficiaries of the concepts and reactions pioneered under the "click chemistry" philosophy. The success of the copper(I) 1,3-dipolar cycloaddition between azides and alkynes, resulting in the triazole ring has inspired the application of other emerging click reactions, for example, Diels-Alder cycloadditions, thiol-ene/yne chemistry, and nitrile N-oxide cycloadditions, towards the creation of advanced functional supramolecular and mechanostereochemical systems. In this Focus Review, recent advances in the use of click chemistry in these fields are highlighted.
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