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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Changes in cardiovascular function with aging.

E G Lakatta1

  • 1Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224.

European Heart Journal
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Cardiovascular function in healthy older adults remains adequate at rest, with some age-related changes like increased heart wall thickness. Exercise capacity declines, influenced by peripheral factors more than central cardiac reserve.

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Area of Science:

  • Cardiovascular Physiology
  • Gerontology
  • Exercise Science

Background:

  • Healthy elderly individuals generally maintain adequate resting cardiovascular function.
  • Age-related cardiac changes include modest increases in heart wall thickness and myocyte size.
  • Diastolic filling rates may decrease, but atrial contribution preserves overall filling volume.

Purpose of the Study:

  • To evaluate cardiovascular function in healthy elderly individuals at rest and during exercise.
  • To understand the impact of aging on cardiac reserve and exercise capacity.
  • To differentiate between central and peripheral factors contributing to age-related decline in physical work capacity.

Main Methods:

  • Assessment of resting heart rate, heart size, and heart wall thickness.
  • Evaluation of diastolic filling rates and atrial contribution to ventricular filling.
  • Measurement of systolic pressure, end-systolic volume, and ejection fraction at rest and during exercise.

Main Results:

  • Resting heart rate is unchanged; heart size is similar, but left ventricular thickness increases.
  • Systolic pressure rises with age, but resting end-systolic volume and ejection fraction remain stable.
  • Physical work capacity declines, with peripheral factors like reduced muscle mass playing a significant role.

Conclusions:

  • Resting cardiovascular function is well-preserved in healthy older adults.
  • Age-related declines in exercise capacity are multifactorial, involving peripheral adaptations.
  • Some elderly individuals can maintain cardiac output during exercise, though with altered hemodynamic responses compared to younger adults.