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Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates
Published on: September 6, 2017
Fast activity during EEG seizures in neonates.
Lakshmi Nagarajan1, Soumya Ghosh, Linda Palumbo
1Department of Neurology, Princess Margaret Hospital for Children, Roberts Road, Subiaco, Perth, WA 6008, Australia. lakshmi.nagarajan@health.wa.gov.au
Epilepsy Research
|September 6, 2011
Summary
Ictal fast activity (FA) on neonatal EEG seizures is strongly linked to clinical symptoms but does not impact neurodevelopmental outcomes.
Area of Science:
- Neonatal neurology
- Epileptology
- Clinical neurophysiology
Background:
- Paroxysmal fast activity (FA) is a potential biomarker for epileptic networks.
- Its presence and significance in neonatal scalp video-electroencephalogram (EEG) seizures require further investigation.
Purpose of the Study:
- To explore the occurrence and clinical significance of ictal FA in neonatal EEG seizures.
- To determine the relationship between ictal FA and electroclinical/electrographic seizures, phenobarbitone use, and neurodevelopmental outcomes.
Main Methods:
- Analysis of 159 neonatal EEG seizures from 42 infants.
- Ictal FA was identified using a 30 Hz low-frequency filter.
- Correlation with electroclinical seizures, phenobarbitone, and neurodevelopmental outcomes was assessed.
Main Results:
- Ictal FA was present in 39% of seizures.
- Seizures with ictal FA were significantly more likely to be electroclinical (55%) than electrographic.
- No association was found between ictal FA and phenobarbitone use, neuroimaging, or neurodevelopmental impairment.
Conclusions:
- Ictal FA on neonatal EEG is highly correlated with clinical seizure manifestations.
- The presence of ictal FA does not appear to affect long-term neurodevelopmental outcomes in neonates.
