Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Home
Closed-loop Stimulation Modulates Attention Shifting In Children.

Home
Closed-loop Stimulation Modulates Attention Shifting In Children.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Deep brain stimulation of the nucleus accumbens for severe self-injurious behaviour in children: long-term outcomes from a first-in-human pilot trial.

Molecular psychiatry·2026

Same author

The Clinician Investigator Program: A Missed Opportunity in the Training of Academic Radiologists in Canada.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes·2026

Same author

Phenotypic Exploration in Patients with Heterozygous Variant in AFG3L2 Gene: A Case-Series and Literature Review.

Movement disorders clinical practice·2026

Same author

GLUT1 Deficiency Syndrome with Coexistent Movement Disorder and Anemia.

Movement disorders clinical practice·2026

Same author

Hidden folds reveal brain organization.

eLife·2026

Same author

Deep brain stimulation or best medical treatment for Parkinson's disease patients: 36-month longitudinal neuropsychological and motor assessment - a prospective case-control study.

Neurologia i neurochirurgia polska·2026

Same journal

Striatal control of amygdalar acetylcholine release during salience-associated processing.

Nature neuroscience·2026

Same journal

Mitochondrial stress response drives microglial senescence.

Nature neuroscience·2026

Same journal

Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior.

Nature neuroscience·2026

Same journal

The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.

Nature neuroscience·2026

Same journal

Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering.

Nature neuroscience·2026

Same journal

DBS: from neuromodulation to neuroremodelling.

Nature neuroscience·2026

See all related articles

Related Experiment Video

Touchscreen Sustained Attention Task (SAT) for Rats

Touchscreen Sustained Attention Task (SAT) for Rats

Published on: September 15, 2017

Closed-loop stimulation modulates attention shifting in children.

Nebras M Warsi^1,2, Simeon M Wong^2,3, Karim Mithani^1,2

¹Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

Nature Neuroscience

|May 13, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Researchers identified a brain signal predicting attention lapses in children. Real-time brain stimulation using this signal improved attention control, offering new therapeutic possibilities for attention deficits.

More Related Videos

New Variations for Strategy Set-shifting in the Rat

New Variations for Strategy Set-shifting in the Rat

Published on: January 23, 2017

Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning

Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning

Published on: October 22, 2015

Related Experiment Videos

Touchscreen Sustained Attention Task (SAT) for Rats

Touchscreen Sustained Attention Task (SAT) for Rats

Published on: September 15, 2017

New Variations for Strategy Set-shifting in the Rat

New Variations for Strategy Set-shifting in the Rat

Published on: January 23, 2017

Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning

Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning

Published on: October 22, 2015

Area of Science:

Neuroscience
Cognitive Science
Neuromodulation

Background:

Spontaneous attention fluctuations disrupt adaptation to changing environments.
Attentional flexibility is impaired in children with attention deficit disorders.
Understanding the neural basis of attentional control is crucial for developing interventions.

Purpose of the Study:

To identify a reproducible neural signature of attentional control in children.
To predict and prevent attention lapses in real time using intracranial recordings.
To explore the potential for targeted neuromodulation to enhance attentional flexibility.

Main Methods:

In vivo intracranial recordings were obtained from children with epilepsy during an attentional set-shifting task.
Machine learning classifiers were trained to predict delays in attention shifting.
Intracranial electrical stimulation was applied in response to predicted attention lapses.
Simultaneous electroencephalography (EEG) was used to identify scalp signatures.

Main Results:

A reproducible neural signature of attentional control was identified.
Machine learning models accurately predicted attention shifting delays.
Intracranial electrical stimulation successfully rescued attention shifts, improving eye tracking, reaction time, and accuracy.
Corresponding scalp signatures were identified via EEG, enabling noninvasive modulation.

Conclusions:

The study reveals a neural basis for attentional shifts and control.
Real-time prediction and modulation of attention lapses are feasible.
Findings have implications for targeted neuromodulation and exogenous attentional control strategies.
This research offers potential for novel interventions for attention deficits.