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Related Experiment Video

Updated: May 29, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

A unified framework for inhibitory control.

Yuko Munakata1, Seth A Herd, Christopher H Chatham

  • 1Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309-0345, USA. munakata@colorado.edu

Trends in Cognitive Sciences
|September 6, 2011
PubMed
Summary
This summary is machine-generated.

The prefrontal cortex (PFC) controls unwanted thoughts and actions by representing goals. This leads to two distinct inhibition types: global for subcortical areas and competitive for neocortical areas, aiding understanding of brain inhibition mechanisms.

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Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
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Related Experiment Videos

Last Updated: May 29, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
08:55

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurobiology

Background:

  • Inhibitory control over thoughts, actions, and emotions is essential for daily functioning.
  • The prefrontal cortex (PFC) is traditionally recognized as a key brain region for executive functions, including inhibition.

Purpose of the Study:

  • To propose a novel framework for understanding the PFC's role in inhibitory control.
  • To differentiate between two distinct mechanisms of inhibition mediated by the PFC.

Main Methods:

  • Theoretical analysis of existing neuroscientific data on PFC function.
  • Conceptual modeling of prefrontal-subcortical and prefrontal-neocortical interactions.

Main Results:

  • The PFC's function is best understood as representing and maintaining abstract information, such as goals.
  • Two types of inhibitory effects are proposed: directed global inhibition of subcortical regions and indirect competitive inhibition within neocortical regions.

Conclusions:

  • Understanding the dual mechanisms of PFC-mediated inhibition is crucial for elucidating how inhibitory control works.
  • These distinctions offer insights into the neural basis of impaired or improved inhibitory functions, relevant for various neurological and psychiatric conditions.