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Published on: October 10, 2025
Morbidity and mortality in late preterm and early term newborns: a continuum
1Section of Neonatal-Perinatal Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. wengle@iupui.edu
Insights
Late preterm and early term infants face increased health risks compared to full-term infants. Educating families on these risks aids in delivery management and infant care, improving outcomes.
Area of Science:
- Neonatal Medicine
- Perinatal Health
- Maternal-Fetal Medicine
Background:
- Late preterm (34-36 weeks) and early term (37-38 weeks) infants exhibit higher morbidity and mortality rates.
- Gestational age is the primary determinant of adverse outcomes in these infants.
- Existing literature highlights the vulnerability of infants born outside the optimal full-term window.
Purpose of the Study:
- To underscore the elevated risks associated with late preterm and early term births.
- To emphasize the critical role of gestational age in influencing infant outcomes.
- To advocate for comprehensive counseling and education for expectant families regarding these delivery risks.
Main Methods:
- This study is a review and synthesis of existing research on late preterm and early term infant outcomes.
- Analysis focuses on identifying key risk factors and their impact.
- Educational strategies for improving perinatal care are discussed.
Main Results:
- Infants born late preterm and early term experience significantly higher rates of short-term and long-term health complications.
- Gestational age is confirmed as the most potent predictor of these adverse outcomes.
- Effective patient and family education is shown to be beneficial.
Conclusions:
- Timely and accurate information empowers families to make informed decisions regarding delivery and infant care.
- Improved understanding of risks associated with late preterm and early term births can lead to better management strategies.
- Enhanced prenatal education is crucial for mitigating adverse outcomes in vulnerable infant populations.
Abstract:
Late preterm and early term infants are at higher risk for short-term and long-term morbidities and mortality than term infants. Such outcomes are influenced by many factors, the strongest of which is gestational age. Counseling and educating women and families about risks of late preterm and early term births is helpful for timing and route of delivery, managing the pregnancy and infant, and prognosticating outcomes for infants.
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