Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Septic cortical thrombophlebitis.

M J DiNubile1, W H Boom, F S Southwick

  • 1Department of Medicine, Cooper Hospital/University Medical Center, Camden, NJ.

The Journal of Infectious Diseases
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence of <i>Mycobacterium tuberculosis</i> infection in an African city with endemic TB.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
Same author

Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2013
Same author

Comparison of time to positive and colony counting in an early bactericidal activity study of anti-tuberculosis treatment.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2013
Same author

Relapse more common than reinfection in recurrent tuberculosis 1-2 years post treatment in urban Uganda.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2013
Same author

A randomized trial of punctuated antiretroviral therapy in Ugandan HIV-seropositive adults with pulmonary tuberculosis and CD4⁺ T-cell counts of ≥ 350 cells/μL.

The Journal of infectious diseases·2011
Same author

Time to detection of Mycobacterium tuberculosis as an alternative to quantitative cultures.

Tuberculosis (Edinburgh, Scotland)·2011
Same journal

NET-inducing ability of Cutibacterium acnes clinical isolates is associated with pathogenicity in acne vulgaris.

The Journal of infectious diseases·2026
Same journal

Optimizing the Use of Proviral DNA HIV Drug Resistance Testing: Clinical Applications and Cautions.

The Journal of infectious diseases·2026
Same journal

Monitoring HLA-A2-restricted T cell responses and BCLA-specific serostatus during human latent Toxoplasma gondii infection suggests the implication of CD8+ T cells in parasite containment.

The Journal of infectious diseases·2026
Same journal

Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French National Reference Center (CEREDIH).

The Journal of infectious diseases·2026
Same journal

Type 3 fimbrial regulation underpins anti-MrkA immunotherapeutic efficacy in experimental Klebsiella pneumoniae infection.

The Journal of infectious diseases·2026
Same journal

Rationalising heterogeneity in Staphylococcus aureus bacteraemia: current progress and future goals.

The Journal of infectious diseases·2026
See all related articles

Septic cortical vein thrombosis is rare in bacterial meningitis and often overshadowed by other complications. This condition is not the primary cause of seizures or focal neurologic deficits in meningitis patients.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pathology

Background:

  • Septic cortical vein thrombosis is a suspected cause of neurological deficits in bacterial meningitis.
  • Its prevalence and significance require further investigation.

Purpose of the Study:

  • To determine the frequency and clinical impact of septic cortical vein thrombosis in bacterial meningitis.
  • To assess its role in causing seizures and focal neurologic deficits.

Main Methods:

  • Retrospective review of medical records, angiograms, and autopsy diagnoses from Massachusetts General Hospital (1960-1984).
  • Identification of patients with septic cortical vein thrombosis without sagittal sinus involvement.
  • Analysis of clinical manifestations, outcomes, and co-existing pathologies.

Related Experiment Videos

Main Results:

  • Only 10 cases of septic cortical vein thrombosis without sagittal sinus thrombosis were confirmed.
  • Meningitis was present in nine patients, with Streptococcus pneumoniae identified in five.
  • Cortical vein thrombosis was found in ~1% of all bacterial meningitis cases and 5% of autopsy cases.
  • Other pathologies like arteritis and cerebral infarctions were more prominent than venous thrombosis in autopsied patients.
  • Fever, seizures, and focal neurologic signs were common; 50% survived, with three experiencing persistent disabilities.

Conclusions:

  • Septic cortical vein thrombosis is an infrequent complication of bacterial meningitis.
  • It is not the predominant cause of seizures or focal neurologic deficits in this patient population.
  • Other pathological processes are often more significant contributors to neurological impairment in meningitis.