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Neuroadaptive changes in cerebellar neurons induced by chronic exposure to IL-6
1Molecular and Integrative Neuroscience Department, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. gruol@scripps.edu
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IL-6 is an important signaling molecule in the CNS. CNS neurons express IL-6 receptors and their signal transduction molecules, consistent with a role for IL-6 in neuronal physiology. Research indicates that IL-6 levels are low in the normal brain but can be significantly elevated in CNS injury and disease. Relatively little is known about how the elevated levels of IL-6 affect neurons. In the current study we show that under conditions of chronic exposure, IL-6 induces alterations in the level of protein expression in developing CNS cells. Such changes may play a role in the altered CNS function observed in CNS conditions associated with elevated levels of IL-6 in the CNS.
