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Updated: May 29, 2026

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Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion
Dawei Li1, Zhaoqi Yang, Yi Long
1RecDivision of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore.
Abstract:
It is demonstrated that the right and left handedness of DNA supercoils can be engineered precisely and readily at the molecular level in vitro through utilization of the invading property of peptide nucleic acid.
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Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
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