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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: May 29, 2026

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
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Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

Fermented wheat germ extract--nutritional supplement or anticancer drug?

Thomas Mueller1, Wieland Voigt

  • 1University of Halle, Department of Internal Medicine, Oncology/Hematology and Hemostaseology, Halle/Saale, Germany.

Nutrition Journal
|September 7, 2011
PubMed
Summary

Fermented wheat germ extract (FWGE) shows promise as a cancer treatment adjunct. Clinical trials suggest FWGE improves progression-free survival and overall survival in cancer patients, warranting further investigation.

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Last Updated: May 29, 2026

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Published on: June 2, 2023

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Fermented wheat germ extract (FWGE) is a complex natural compound.
  • FWGE contains active benzoquinones and modulates key cellular pathways like glycolysis and apoptosis.
  • It exhibits antiproliferative, antimetastatic, and immunomodulatory effects.

Purpose of the Study:

  • To evaluate the efficacy and safety of FWGE in cancer treatment.
  • To explore FWGE's synergistic effects with conventional chemotherapy.
  • To assess FWGE's impact on patient survival and quality of life.

Main Methods:

  • Preclinical studies in rat models for colon cancer prevention.
  • Phase II clinical trial in melanoma patients combining FWGE with dacarbazine.
  • Analysis of progression-free survival (PFS), overall survival (OS), and quality of life data.

Main Results:

  • FWGE demonstrated colon cancer preventing effects in rat models.
  • Melanoma patients treated with FWGE and dacarbazine showed significant improvements in PFS and OS.
  • FWGE treatment was associated with improved quality of life in several studies.

Conclusions:

  • Current data support FWGE's use as a medical nutriment for cancer patients.
  • Further large-scale, randomized clinical trials are necessary to confirm FWGE's role in chemotherapy regimens.