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Updated: May 29, 2026
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Endothelin in chronic proteinuric kidney disease
Contributions to Nephrology
|September 7, 2011
Summary
Chronic kidney diseases are rising globally. This review explores Endothelin (ET)-1
Area of Science:
- Nephrology
- Pharmacology
- Molecular Biology
Background:
- Chronic kidney diseases (CKD) incidence is increasing worldwide.
- Endothelin (ET)-1 plays a significant role in renal physiology and pathology.
- ET-1 exhibits vasoconstrictor, proinflammatory, mitogenic, and profibrotic effects in the kidneys.
Purpose of the Study:
- To review the role of ET-1 in kidney diseases.
- To discuss novel pharmacological treatments for chronic nephropathies.
- To explore the therapeutic potential of ET receptor antagonists.
Main Methods:
- Literature review of experimental and clinical studies.
- Analysis of the role of ET-1 and its receptors in renal disorders.
- Evaluation of ET receptor antagonists' effectiveness in animal models.
Main Results:
- ET-1 contributes to the progression of various renal disorders.
- ET receptor antagonists have shown effectiveness in improving renal hemodynamics and reducing fibrosis in experimental animals.
- The optimal choice between selective ET(A) or dual ET(A)/ET(B) antagonists remains under investigation.
Conclusions:
- ET-1 is a key mediator in chronic kidney diseases.
- ET receptor antagonists represent a promising therapeutic strategy.
- Combined therapies, including ET receptor antagonists, may enhance renoprotection, especially in later disease stages.
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