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Strontium doping of bone graft extender
Marianne T Vestermark1, Ellen-Margrethe Hauge, Kjeld Soballe
1Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Denmark. marianne.t@vestermark.dk
Acta Orthopaedica
|September 8, 2011
Summary
Strontium-doped bone graft extenders improved allograft bone healing and preservation in revision hip surgery. However, this did not enhance implant mechanical fixation in a canine model.
Area of Science:
- Orthopedic Surgery
- Biomaterials Science
- Bone Regeneration
Background:
- Allografts are crucial for implant stabilization in revision hip replacement.
- Implant instability can arise from excessive allograft resorption and insufficient new bone formation.
- Strontium's dual anabolic and anticatabolic properties were investigated for bone regeneration.
Purpose of the Study:
- To evaluate strontium's effect on balancing allograft resorption and bone formation.
- To assess if strontium doping of hydroxyapatite bone graft extenders improves outcomes in a canine model.
- To determine if strontium enhances osseointegration and mechanical fixation.
Main Methods:
- Titanium implants were placed in a bone gap filled with allograft and either strontium-doped (SrHA) or undoped (HA) hydroxyapatite bone graft extender in dogs.
- Osseointegration and mechanical fixation were assessed after 4 weeks using histomorphometry and push-out tests.
- The study compared outcomes between SrHA and HA bone graft extender groups.
Main Results:
- SrHA significantly increased new bone volume (1.2-fold), preserved allograft volume (1.2-fold), and enhanced bone-to-extender contact (1.4-fold) compared to HA.
- No significant improvements were observed in bone ongrowth onto implants or mechanical push-out parameters with SrHA.
- Statistical significance was achieved for all observed increases in bone healing metrics.
Conclusions:
- Strontium doping of hydroxyapatite bone graft extenders enhances gap healing and allograft preservation.
- Increased contact between new bone and the bone graft extender material was observed with strontium.
- Strontium doping did not improve the mechanical fixation of implants in this study.
