Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk.

Cerebral cortex (New York, N.Y. : 1991)·2022
Same author

The dynamic interplay between sleep and mood: an intensive longitudinal study of individuals with bipolar disorder.

Psychological medicine·2022
Same author

Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk.

Translational psychiatry·2021
Same author

Genomic and Imaging Biomarkers in Schizophrenia.

Current topics in behavioral neurosciences·2018
Same author

Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation.

Psychological medicine·2018
Same author

Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia.

Molecular psychiatry·2018

Related Experiment Video

Updated: May 29, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

Recent genomic advances in schizophrenia.

J L Doherty1, M C O'Donovan, M J Owen

  • 1MRC Centre for Neuropsychiatric Genetics and Genomics, and Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.

Clinical Genetics
|September 8, 2011
PubMed
Summary

Schizophrenia heritability involves common and rare genetic variants. Copy number variations (CNVs) confer high risk, suggesting shared genetic links with other neurodevelopmental disorders.

More Related Videos

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

Related Experiment Videos

Last Updated: May 29, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

Area of Science:

  • Psychiatric Genetics
  • Neuroscience
  • Genomics

Background:

  • Schizophrenia heritability is high, suggesting complex genetic underpinnings.
  • Population genetics predicts a mix of common and rare alleles contributing to risk.
  • Previous assumptions of genetic distinctness between schizophrenia and bipolar disorder are being challenged.

Purpose of the Study:

  • To explore the genetic architecture of schizophrenia, integrating findings from common and rare variants.
  • To investigate the role of copy number variations (CNVs) in schizophrenia risk.
  • To examine potential genetic overlap between schizophrenia and other neurodevelopmental disorders.

Main Methods:

  • Genome-wide association studies (GWAS) to identify common risk loci.
  • Analysis of submicroscopic chromosomal abnormalities, specifically copy number variations (CNVs).
  • Review of existing literature on genetic variants, including NRXN1 deletions.

Main Results:

  • GWAS identified significant risk loci and a substantial burden of common risk alleles.
  • Evidence suggests genetic overlap between schizophrenia and bipolar disorder.
  • Genome-wide studies indicate that copy number variations (CNVs) confer high risk for schizophrenia.
  • Specific large CNVs and NRXN1 deletions are implicated in schizophrenia susceptibility.
  • Many identified CNVs are also associated with autism, mental retardation, and epilepsy.

Conclusions:

  • Schizophrenia's genetic basis is a combination of common and rare variants, including CNVs.
  • The findings challenge traditional nosology and suggest shared genetic pathways with other neurodevelopmental disorders.
  • Implications for understanding schizophrenia pathogenesis and guiding future genetic research are significant.