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Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Neonatal morbidity in singleton late preterm infants compared with full-term infants.

A Leone1, P Ersfeld, M Adams

  • 1Division of Neonatology, Department of Obstetrics and Gynecology, University Hospital Zurich, Switzerland. antonio.leone@usz.ch

Acta Paediatrica (Oslo, Norway : 1992)
|September 8, 2011
PubMed
Summary

Late preterm infants (34-36 weeks gestation) experience significantly higher short-term morbidity and longer hospital stays than full-term infants. These findings highlight increased healthcare needs for late preterm infants.

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Area of Science:

  • Neonatal Medicine
  • Pediatrics
  • Public Health

Background:

  • Late preterm infants, born between 34 and 36 weeks of gestation, represent a growing population with unique health considerations.
  • Existing research suggests potential vulnerabilities in this group compared to full-term infants, necessitating further investigation.

Purpose of the Study:

  • To test the hypothesis that singleton late preterm infants have a higher incidence of short-term morbidity and longer hospitalizations than full-term infants.
  • To quantify the differences in specific morbidities and hospital stay duration between these two infant groups.

Main Methods:

  • Retrospective, multicentre study analyzing electronic health data from five Swiss hospitals.
  • Comparison of short-term outcomes between 530 late preterm infants and 1686 full-term infants.
  • Exclusion of multiple gestations, fetal malformations, maternal drug use, and incomplete data; results corrected for gender imbalance.

Main Results:

  • Late preterm infants showed significantly higher rates of respiratory distress (34.7% vs. 4.6%), hyperbilirubinemia (47.7% vs. 3.4%), hypoglycemia (14.3% vs. 0.6%), and hypothermia (2.5% vs. 0.6%).
  • Hospitalization duration was longer for late preterm infants (mean 9.9 days vs. 5.2 days).
  • The risk of at least one complication was 7.6 times higher in late preterm infants (70.8%) compared to full-term infants (9.3%).

Conclusions:

  • Singleton late preterm infants exhibit a considerably higher rate of medical complications and prolonged hospital stays than matched full-term infants.
  • These findings indicate a greater need for medical and financial resources for the care of late preterm infants.
  • The study underscores the importance of targeted monitoring and resource allocation for late preterm neonates.