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Published on: November 6, 2019
Effectiveness of adenoidectomy in children with recurrent upper respiratory tract infections: open randomised
M T A van den Aardweg1, C W B Boonacker, M M Rovers
1Department of Otorhinolaryngology, University Medical Centre Utrecht, Netherlands.
Insights
Adenoidectomy offers no clinical benefit for children with recurrent upper respiratory tract infections compared to watchful waiting. Immediate surgery did not reduce infection rates and led to more fever days.
Area of Science:
- Pediatric Otolaryngology
- Infectious Diseases
- Clinical Trials
Background:
- Recurrent upper respiratory tract infections (URTIs) are common in children.
- Adenoidectomy is a frequent surgical intervention for these conditions.
- Evidence on its comparative effectiveness is crucial.
Purpose of the Study:
- To evaluate the clinical effectiveness of adenoidectomy versus watchful waiting for recurrent URTIs in children.
- To compare infection rates, symptom duration, and quality of life between the two strategies.
Main Methods:
- An open randomized controlled trial was conducted across 11 general and 2 academic hospitals.
- 111 children aged 1-6 with recurrent URTIs were randomized to immediate adenoidectomy or watchful waiting.
- Primary outcome was the number of URTIs per person-year over 24 months.
Main Results:
- No significant difference in the incidence of URTIs per person-year between adenoidectomy (7.91) and watchful waiting (7.84) groups.
- Similar outcomes observed for days with URTIs, middle ear complaints, and health-related quality of life.
- Adenoidectomy group experienced more days with fever; two surgical complications occurred.
Conclusions:
- Immediate adenoidectomy provides no additional clinical benefit over watchful waiting for children with recurrent URTIs.
- Watchful waiting is a viable alternative strategy, avoiding surgical risks.
- Further research may explore specific subgroups benefiting from adenoidectomy.
Objective:
To assess the effectiveness of adenoidectomy in children with recurrent upper respiratory tract infections.
Design:
Open randomised controlled trial.
Setting:
11 general hospitals and two academic centres.
Participants:
111 children aged 1-6 with recurrent upper respiratory tract infections selected for adenoidectomy.
Intervention:
A strategy of immediate adenoidectomy with or without myringotomy or a strategy of initial watchful waiting. Main outcome measure Primary outcome measure: number of upper respiratory tract infections per person year calculated from data obtained during the total follow-up (maximum 24 months).
Secondary Outcome Measures:
days with upper respiratory tract infection per person year, middle ear complaints with fever in episodes and days, days with fever, prevalence of upper respiratory tract infections, and health related quality of life.
Results:
During the median follow-up of 24 months, there were 7.91 episodes of upper respiratory tract infections per person year in the adenoidectomy group and 7.84 in the watchful waiting group (difference in incidence rate 0.07, 95% confidence interval -0.70 to 0.85). No relevant differences were found for days of upper respiratory tract infections and middle ear complaints with fever in episodes and days, nor for health related quality of life. The prevalence of upper respiratory tract infections decreased over time in both groups. Children in the adenoidectomy group had significantly more days with fever than the children in the watchful waiting group. Two children had complications related to surgery.
Conclusion:
In children selected for adenoidectomy for recurrent upper respiratory tract infections, a strategy of immediate surgery confers no clinical benefits over a strategy of initial watchful waiting. Trial registration Dutch Trial Register NTR968: ISRCTN03720485.
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