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Ocular Behçet disease: current therapeutic approaches
1Division of Uvea-Behçet Unit, Department of Ophthalmology, Erciyes University Medical Faculty, Kayseri, Turkey. evereklioglu@erciyes.edu.tr
Current Opinion in Ophthalmology
|September 8, 2011
Summary
Ocular Behçet disease (OBD) requires prompt recognition and treatment. Advanced therapies like biologics show promise for managing severe ocular inflammation and preventing vision loss.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Ocular Behçet disease (OBD) is a severe inflammatory condition affecting the eye.
- It predominantly impacts young adults, potentially leading to significant vision impairment.
Purpose of the Study:
- To highlight the importance of early diagnosis and current treatment strategies for recurrent hypopyon iridocyclitis and panuveitis in OBD.
- To inform physicians about the evolving therapeutic landscape for ocular inflammation in Behçet disease.
Main Methods:
- Review of current literature on the treatment of ocular inflammation in Behçet disease.
- Focus on emerging biologic therapies and their efficacy.
Main Results:
- Biologic agents, including interferon-α, rituximab, and TNF inhibitors (infliximab, adalimumab), are increasingly used.
- These treatments are effective for severe sight-threatening conditions like retinal vasculitis and cystoid macular edema (CME).
Conclusions:
- Biological agents hold significant potential for managing OBD.
- Early ophthalmologic consultation is crucial for patients with systemic Behçet disease to prevent sight-threatening complications.
- Infliximab is effective for acute panuveitis, with repeated infusions beneficial for refractory uveoretinitis and CME remission.
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