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Mania associated with complicated hereditary spastic paraparesis
Raghavendra B Nayak1, Govind S Bhogale, Nanasaheb M Patil
1Department of Psychiatry, Jawaharlal Nehru Medical College, KLE University, Belgaum, Karnataka, India.
Journal of Neurosciences in Rural Practice
|September 8, 2011
Summary
This case report details a rare instance of a 17-year-old male with hereditary spastic paraplegia (HSP) experiencing a first episode of mania. The study highlights the unusual co-occurrence of neurological and psychiatric conditions.
Area of Science:
- Neurology
- Psychiatry
- Genetics
Background:
- Hereditary spastic paraplegia (HSP) comprises inherited neurological disorders characterized by progressive lower limb spasticity.
- HSP is clinically classified into pure and complicated forms, with pure HSP lacking associated neurological or psychiatric comorbidities.
- Depression is the most frequent psychiatric comorbidity in HSP patients.
Observation:
- A rare case of a 17-year-old male with classical HSP features is presented.
- The patient exhibited symptoms of mania, including excessive happiness, irritability, inflated self-esteem, and reduced sleep for one month.
- The patient also experienced complex partial seizures concurrent with HSP symptoms.
Findings:
- The patient's family history includes pure HSP in his father and younger sister.
- The diagnosis was established as a first episode of mania in the context of complicated hereditary spastic paraplegia.
- This case represents an unusual presentation of bipolar affective illness alongside HSP.
Implications:
- This report underscores the importance of considering psychiatric comorbidities in hereditary spastic paraplegia.
- Investigating the neurobiological underpinnings of this rare association may offer new insights into both HSP and bipolar disorder.
- Further research is warranted to understand the genetic and neurobiological links between HSP and mania.
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